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Preiss–Handler and de novo do not occur within the mitochondria, based on the nuclear or cytosolic localization of QPRT, NAPRT, and NADS 48

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Nrf2 leads to the inhibition of nuclear factor kappa B (NF-κB), activator protein-1 (AP-1) and mitogen-activated protein kinase (MAPK) classical inflammatory pathways, resulting in decreased expression of the inflammatory mediators (iNOS, COX-2, NO and prostaglandins) and pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β)